Thymoma diagnosis in a 37-year old woman hospitalized for SARS-CoV-2 infection: Α case report
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Pneumonology Department of General Hospital of Serres, Greece
Publication date: 2021-08-31
Corresponding author
Antonis Antoniadis   

Pneumonology Clinic, General Hospital of Serres, Greece
Pneumon 2020;33(4):1-4
A 37-year-old woman with recent travel history from the UK presented to the emergency department with high fever, dry cough and weakness. Due to the COVID-19 pandemic she was admitted to the isolated COVID-19 unit and tested positive for SARS-CoV-2 through pharyngeal swab PCR. Chest x-ray revealed no lung opacities rather than mediastinum enlargement. CT scan showed a mediastinum mass and small subpleural lung opacities bilaterally. PET SCAN was performed followed by radical excision of the mass through VATS. The histologic analysis revealed type B2 Thymoma with partial invasion of the capsule, thus the patient underwent postoperative radiotherapy. This case report could be the principle for further investigation in the field of association between thymous gland and SARS-COV-2 infection through immunity pathway disorders.
Shelly S, Agmon-Levin N, Altman A, et al. Thymoma and autoimmunity. Cellular & Molecular Immunology 2011; 8:199–202.
Savino W. The thymus is a common target organ in infectious diseases. PLoS Pathog 2006;2:e62.
Albano F, Vecchio E, Renna M et al. Insights into thymus development and viral thymic 263 infections. Viruses 2019; 11:836.
Savino W, Dardenne M, Marche C, et al. Thymic epithelium in AIDS: An immunohistologic study. Am J Pathol 1986; 122:302–7.
Dooley J, Liston A. Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue. Eur J Immunol 2012; 42:1073-9.
Nunes-Alves C, Nobrega C, Behar SM, et al. Tolerance has its limits: how the thymus copes with infection. Trends Immunol 2013;34:502-10.
Raphael Ho Tsong Fang, Colantonio AD, Vittenbogaart CH. The role of the thymus in HIV infection: a 10 year perspective. AIDS 2008; 11;22:171-84.
Cuvelier Pelagia, Roux H, Couedel-Courteille A et al. Protective Thymus Hyperplasia in the COVID-19 Acute Respiratory Distress Syndrome, Research 8/2020 (under review).
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