Quality of sleep in patients with end-stage renal failure
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Pulmonary Department, General Hospital “Papageorgiou”, Thessaloniki, Greece
Laboratory of Immunology - Histocompatibility, General Hospital “Papageorgiou ”, Thessaloniki, Greece
Laboratory of Experimental Physiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Laboratory of Forensic and Toxicology, Department of Autopsy Histopathology, Aristotle University of Thessaloniki, Greece
Department of Pulmonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
Corresponding author
Drosos Tsavlis   

Laboratory of Experimental Physiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
Pneumon 2019;32(1-2):23-30
Restless syndrome (RLS) is a common disorder of the lower limbs, characterized by an intense need for continuous movement and accompanied usually by unpleasant sensations. In patients with End-Stage Renal Disease (ESRD) under hemodialysis and under peritoneal dialysis, the syndrome has not been thoroughly studied, particularly in the Greek population. The aim of the study was to assess the prevalence of RLS in ESRD.

Material and Methods:
ESRD patients underwent laboratory examinations and completed the Pittsburgh Sleep Quality Index (PSQI) questionnaire. It is a cross sectional study and the syndrome RLS was diagnosed according to the International Restless Legs criteria.

RLS prevalence was 30% among ESRD patients with a higher prevalence among patients under peritoneal dialysis. The value of urea, β2- microglobulin and parathyroid hormone was related to the scores of the individual components of the PSQI questionnaire. Gender was not statistically associated with the presence of RLS. C

The current study demonstrated that 3 out of 10 patients with ESRD suffer from RLS, with the relative risk being increased in patients with high levels of parathyroid hormone. No association was found between hematocrit levels and hemodialysis characteristics. The value of urea, β2- microglobulin and parathyroid hormone was related with the scores of the individual components of the PSQI.

RLS: Restless Legs Syndrome, PSQI: Pittsburgh Sleep Quality Index, CKD: Chronic Kidney Disease, IRLSSG: International Restless Legs Syndrome, Study Group, PTH: Parathyroid Hormone, HTC: Hematocrit, B2M: B2 Microglobulin
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