A 37-year-old woman with recent travel history from the UK presented to the emergency department with high fever, dry cough and weakness. Due to the COVID-19 pandemic she was admitted to the isolated COVID-19 unit and tested positive for SARS-CoV-2 through pharyngeal swab PCR. Chest x-ray revealed no lung opacities rather than mediastinum enlargement. CT scan showed a mediastinum mass and small subpleural lung opacities bilaterally. PET SCAN was performed followed by radical excision of the mass through VATS. The histologic analysis revealed type B2 Thymoma with partial invasion of the capsule, thus the patient underwent postoperative radiotherapy. This case report could be the principle for further investigation in the field of association between thymous gland and SARS-COV-2 infection through immunity pathway disorders.