Department of Respiratory Medicine, Sleeprelated Breathing Disorders Laboratory, University of Thessaly Medical School Larissa, Greece
2
Sleep Study Unit, Eginition Hospital, University of Athens Medical School, Athens, Greece
CORRESPONDING AUTHOR
Dimitra I. Siachpazidou
Department of Respiratory
Medicine, University of Thessaly, Laboratory of
Respiratory Sleep Disorders, University Hospital of
Larissa, Mezourlo Postcode 41110 Larissa, Greece
Purpose: To summarize the information of published studies on
the effect of OSAS on the executive functions of the brain in adult
patients before and after any treatment.
Method: An extensive
literature search was performed on the Pub Med database.
Results: The OSAS inarguably causes neurocognitive deficit and reduced
activation of brain regions responsible for cognitive function. The
methods of treatment are: by a continuous positive air pressure (CPAP)
device, mandibular treatment and tonsillectomy. These methods of
treatment offer some protection to the cognitive areas of the brain.
The severity of the syndrome correlates significantly with the scores
of various neuropsychological batteries; these batteries vary even
if they evaluate the same function.
Conclusions: The severity
of the syndrome is responsible for the degree of neurocognitive
dysfunction. The most prevalent form of treatment is the use of a
device with positive air pressure CPAP which acts as a protective
factor in neurocognitive functions. Further research is needed because few studies have evaluated the effects of treatment using a
CPAP device while the timeframe and the population that needs to
be studied remain uncertain.
REFERENCES(64)
1.
American Thoracic Society. Standards and indications for cardiopulmonary sleep studies in children. American of Journal of Respiratory and Critical Care Medicine 1996; 153:855-78.
Cai A, Zhou Y, Zhang J, Zhong Q, Wang R, Wang L. Epidemiological characteristics and gender-specific differences of obstructive sleep apnea in a Chinese hypertensive population: a cross-sectional study. BMC Cardiovasc Disord 2017; 17:8.
Blackwell T, Yaffe K, Ancoli-Israel S, et al. Associations between sleep architecture and sleep-disordered breathing and cognition in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc 2011; 59:2217-25.
Peng Y, Ouyang R, Cao Y, Chen P, Chen Y. Memory and executive dysfunction in patients with severe obstructive sleep apnea and hypopnea syndrome. Zhonghua Jie He He Hu Xi Za Zhi 2015; 38:756-60.
Baril AA, Gagnon K, Arbour C, et al. Regional cerebral blood flow during wakeful rest in older subjects with mild to severe obstructive sleep apnea. Sleep 2015, 38:1439-49.
Duffy SL, Lagopoulos J, Terpening Z, et al. Association of anterior cingulate glutathione with sleep apnea in older adults at-risk for dementia. Sleep 2016; 39:899-906.
Andreou G, Vlachos F, Makanikas K. Effects of chronic obstructive pulmonary disease and obstructive sleep apnea on cognitive functions: Evidence for a common nature. Sleep Disord 2014; 2014:768210.
Tegelberg A, Wilhelmsson B, Erixon-Lindroth N, Lindström LH. Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea. Nat Sci Sleep 2012; 4:89–96.
Canessa N, Castronovo V, Cappa SF, et al. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med 2011; 183:1419-26.
Crawford-Achour E, Dauphinot V, Martin MS, et al. Protective effect of long-term CPAP therapy on cognitive performance in elderly patients with severe OSA: The PROOF study. J Clin Sleep Med 2015; 11:519-24.
Montplaisir J, Bédard MA, Richer F, Rouleau I. Neurobehavioral manifestations in obstructive sleep apnea syndrome before and after treatment with continuous positive airway pressure. Sleep 1992; 15(6 Suppl):S17-9.
Edwards KM, Kamat R, Tomfohr LM, Ancoli-Israel S, Dimsdale JE.Obstructive sleep apnea and neurocognitive performance: the role of costisol. Sleep Med 2014; 15:27-32.
Alchanatis M, Deligiorgis N, Zias N, et al. Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study. Eur Respir J 2004; 24:980-6.
Hrubos-Strøm H, Nordhus IH, Einvik G, et al. Obstructive sleep apnea, verbal memory, and executive function in a communitybased high-risk population identified by the Berlin Questionnaire Akershus Sleep Apnea Project. Sleep Breath 2012; 16:223-31.
Verstraeten E, Cluydts R, Pevernagie D, Hoffmann G. Executive function in sleep apnea: controlling for attentional capacity in assessing executive attention. Sleep 2004; 27:685-93.
Quan SF, Wright R, Baldwin CM, et al. Obstructive sleep apneahypopnea and neurocognitive functioning in the Sleep Heart Health Study. Sleep Med 2006; 7:498-507.
Delazer M, Zamarian L, Frauscher B, et al. Oxygen desaturation during night sleep affects decision-making in patients with obstructive sleep apnea. J Sleep Res 2016; 25:395-403.
Chen X, Zhang R, Xiao Y, Dong J, Niu X, Kong W. Reliability and validity of the beijing version of the Montreal cognitive assessment in the evaluation of cognitive function of adult patients with OSAHS. PLoS One 2015; 10:e0132361.
Shpirer I, Elizur A, Shorer R, Peretz RB, Rabey JM, Khaigrekht M. Hypoxemia correlates with attentional dysfunction in patients with obstructive sleep apnea. Sleep Breath 2012; 16:821-7.
Lis S, Krieger S, Hennig D, et al. Executive functions and cognitive subprocesses in patients with obstructive sleep apnoea. J Sleep Res 2008; 17:271-80.
Yılmaz Z, Voyvoda N, İnan E, Şirinocak PB, Terzi R. Factors affecting executive functions in obstructive sleep apnea syndrome and volumetric changes in the prefrontal cortex. Springerplus 2016; 5:1934.
Zhang X, Ma L, Li S, Wang Y, Wang L. A functional MRI evaluation of frontal dysfunction in patients with severe obstructive sleep apnea. Sleep Med 2011; 12:335-40.
Morisson F, Lavigne G, Petit D, Nielsen T, Malo J, Montplaisir J. Spectral analysis of wakefulness and REM sleep EEG in patients with sleep apnoea syndrome. Eur Respir J 1998; 11:1135-40.
Nemeth D, Csábi E, Janacsek K, Várszegi M, Mari Z. Intact implicit probabilistic sequence learning in obstructive sleep apnea. J Sleep Res 2012; 21:396-401.
Sharma H, Sharma SK, Kadhiravan T, et al. Pattern & correlates of neurocognitive dysfunction in Asian Indian adults with severe obstructive sleep apnoea. Indian J Med Res 2010; 132:409-14.
Olaithe M, Skinner TC, Hillman D, Eastwood PE, Bucks RS. Cognition and nocturnal disturbance in OSA: the importance of accounting for age and premorbid intelligence. Sleep Breath 2015; 19:221-30.
Borges JG, Ginani GE, Hachul H. Executive functioning in obstructive sleep apnea syndrome patients without comorbidities: focus on the fractionation of executive functions. J Clin Exp Neuropsychol 2013; 35:1094-107.
Salorio CF, White DA, Piccirillo J, Duntley SP, Uhles ML. Learning, memory, and executive control in individuals with obstructive sleep apnea syndrome. J Clin Exp Neuropsychol 2002; 24:93-100.
Crawford-Achour E, et al. Protective Effect of Long-Term CPAP Therapy on Cognitive Performance in Elderly Patients with Severe OSA: The PROOF Study. J Clin Sleep Med 2015; 11:519-24.
Canessa N, et al. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med 2011; 183:1419-26.
Kushida CA, Nichols DA, Holmes TH, et al. Effects of continuous positive airway pressure on neurocognitive function in obstructive sleep apnea patients: The Apnea Positive Pressure Longterm Efficacy Study (APPLES). Sleep 2012; 35:1593-602.
Lau EY, Eskes GA, Morrison DL, Rajda M, Spurr KF. Executive function in patients with obstructive sleep apnea treated with continuous positive airway pressure. J Int Neuropsychol Soc 2010; 16:1077-88.
Dalmases M, Solé-Padullés C, Torres M, et al. Effect of CPAP on cognition, brain function, and structure among elderly patients with OSA: A randomized pilot study. Chest 2015, 148:1214-23.
Saunamäki T, Himanen SL, Polo O, Jehkonen M. Executive dysfunction and learning effect after continuous positive airway pressure treatment in patients with obstructive sleep apnea syndrome. Eur Neurol 2010; 63:215-20.
Décary A, Rouleau I, Montplaisir J. Cognitive deficits associated with sleep apnea syndrome: a proposed neuropsychological test battery. Sleep 2000; 23:369-81.
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