Follicular bronchiolitis in an adult patient with common variable immunodeficiency: 3-year follow-up
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Pneumonology Department, Aristotle University of Thessaloniki, G. Papanikolaou” General Hospital, Exochi, Thessaloniki
Pathology Department, “G. Papanikolaou” General Hospital, Thessaloniki
2nd Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokratio Hospital, Thessaloniki
Despina Papakosta   

Pneumonology Department Aristotle University of Thessaloniki, 13 P. Kavda Street, N. 751 Panorama, 55236 Thessaloniki
Publication date: 2021-07-05
Pneumon 2014;27(2):163–168
Pulmonary manifestations of common variable immunodeficiency, apart from lung infections, include interstitial lung disease such as bronchiolitis. Follicular bronchiolitis as a result of immunodeficiency is mostly described in children. The interesting case of a 35 year old female patient is presented. The patient was admitted to our Department for the investigation of fever up to 38.5 οC for a period of 3 months. The patient had been diagnosed with follicular bronchiolitis 2 years ago. Upon admission the patient was febrile and presented mild cough. Blood tests revealed anemia and leucopenia. Chest-X ray was normal, but the high-resolution CT scan showed subcarinal lymph nodes, ground glass opacities and nodules. Bronchoscopy revealed no specific findings. Bronchoalveolar lavage showed a high percentage of lymphocytes. The results of pulmonary function tests revealed a restrictive disorder. Due to raised suspicion for a lymphoproliferative disease, the patient underwent bone marrow biopsy that was normal. A significant decrease of IgA, IgM and IgG was afterwards detected and the patient was diagnosed with common variable immunodeficiency. Subsequently she started treatment with intravenous immunoglobulin. The patient’s follow-up 3 years after the immunodeficiency diagnosis as well as response to treatment are presented.
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