CASE REPORT
Follicular bronchiolitis in an adult patient with common variable immunodeficiency: 3-year follow-up
 
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1
Pneumonology Department, Aristotle University of Thessaloniki, G. Papanikolaou” General Hospital, Exochi, Thessaloniki
 
2
Pathology Department, “G. Papanikolaou” General Hospital, Thessaloniki
 
3
2nd Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokratio Hospital, Thessaloniki
 
 
Publication date: 2021-07-05
 
 
Corresponding author
Despina Papakosta   

Pneumonology Department Aristotle University of Thessaloniki, 13 P. Kavda Street, N. 751 Panorama, 55236 Thessaloniki
 
 
Pneumon 2014;27(2):163-168
 
KEYWORDS
ABSTRACT
Pulmonary manifestations of common variable immunodeficiency, apart from lung infections, include interstitial lung disease such as bronchiolitis. Follicular bronchiolitis as a result of immunodeficiency is mostly described in children. The interesting case of a 35 year old female patient is presented. The patient was admitted to our Department for the investigation of fever up to 38.5 οC for a period of 3 months. The patient had been diagnosed with follicular bronchiolitis 2 years ago. Upon admission the patient was febrile and presented mild cough. Blood tests revealed anemia and leucopenia. Chest-X ray was normal, but the high-resolution CT scan showed subcarinal lymph nodes, ground glass opacities and nodules. Bronchoscopy revealed no specific findings. Bronchoalveolar lavage showed a high percentage of lymphocytes. The results of pulmonary function tests revealed a restrictive disorder. Due to raised suspicion for a lymphoproliferative disease, the patient underwent bone marrow biopsy that was normal. A significant decrease of IgA, IgM and IgG was afterwards detected and the patient was diagnosed with common variable immunodeficiency. Subsequently she started treatment with intravenous immunoglobulin. The patient’s follow-up 3 years after the immunodeficiency diagnosis as well as response to treatment are presented.
 
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