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CASE REPORT
Follicular bronchiolitis in an adult patient with common variable immunodeficiency: 3-year follow-up
| 1 | Pneumonology Department, Aristotle
University of Thessaloniki, G. Papanikolaou”
General Hospital, Exochi, Thessaloniki |
| 2 | Pathology Department, “G. Papanikolaou”
General Hospital, Thessaloniki |
| 3 | 2nd Department of Internal Medicine, Aristotle
University of Thessaloniki, Hippokratio
Hospital, Thessaloniki |
CORRESPONDING AUTHOR
Despina Papakosta
Pneumonology Department Aristotle University of Thessaloniki, 13 P. Kavda Street, N. 751 Panorama, 55236 Thessaloniki
Pneumonology Department Aristotle University of Thessaloniki, 13 P. Kavda Street, N. 751 Panorama, 55236 Thessaloniki
Publication date: 2021-07-05
Pneumon 2014;27(2):163–168
KEYWORDS
ABSTRACT
Pulmonary manifestations of common variable immunodeficiency, apart from lung infections, include interstitial lung
disease such as bronchiolitis. Follicular bronchiolitis as a result of
immunodeficiency is mostly described in children. The interesting
case of a 35 year old female patient is presented. The patient was
admitted to our Department for the investigation of fever up to 38.5
οC for a period of 3 months. The patient had been diagnosed with
follicular bronchiolitis 2 years ago. Upon admission the patient was
febrile and presented mild cough. Blood tests revealed anemia and
leucopenia. Chest-X ray was normal, but the high-resolution CT scan
showed subcarinal lymph nodes, ground glass opacities and nodules.
Bronchoscopy revealed no specific findings. Bronchoalveolar lavage
showed a high percentage of lymphocytes. The results of pulmonary
function tests revealed a restrictive disorder. Due to raised suspicion
for a lymphoproliferative disease, the patient underwent bone marrow biopsy that was normal. A significant decrease of IgA, IgM and
IgG was afterwards detected and the patient was diagnosed with
common variable immunodeficiency. Subsequently she started treatment with intravenous immunoglobulin. The patient’s follow-up 3
years after the immunodeficiency diagnosis as well as response to
treatment are presented.
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