CASE REPORT
Mixed Allergic Bronchopulmonary : Aspergillosis and Candidiasis
 
More details
Hide details
1
Division of Internal Medicine, Hygeia General Hospital, Athens, Greece
 
2
Department of Pneumonology, Medical School, Democritus University of Thrace, Greece
 
 
Corresponding author
Aikaterini Spyridaki   

Hygeia Hospital, Athens, Maroussi, GR-151 23, 4 Erithrou Stavrou Str. & Kifissias Ave., Greece
 
 
Pneumon 2014;27(2):152-156
 
KEYWORDS
ABSTRACT
A 67 year-old woman presented with dyspnea, fever and productive cough. She was a heavy smoker (80 pack/years), with history of hypertension and alcohol consumption. Chest CT revealed bilateral diffuse infiltrates and ground glass opacities. Sputum cultures revealed multiple colonies of C. albicans and cytology showed spores and hyphae of Candida. The patient had positive skin prick test for Candida and elevated IgE level (IgE= 543 IU/mL). Allergic bronchopulmonary candidiasis was diagnosed, the patient received corticosteroids and fluconazole and showed clinical improvement. After 20 days, her symptoms reappeared as she reported poor compliance to her medication. Sputum cultures revealed A. niger colonies, one sample yielded both Aspergillus and Candida colonies. Precipitating antibodies and specific IgG and IgE against Aspergillus were present in patient's serum. Diagnosis was revised to mixed allergic bronchopulmonary aspergillosis and candidiasis. The patient received corticosteroids and voriconazole and improved.
REFERENCES (13)
1.
Hinson KF, Moon AJ, Plummer NS. Broncho-pulmonary aspergillosis; a review and a report of eight new cases. Thorax 1952;7:317-333.
 
2.
Donnelly SC, McLaughlin H, Bredin CP. Period prevalence of allergic bronchopulmonary mycosis in a regional hospital outpatient population in Ireland 1985-88. Ir J Med Sci 1991;160:288-290.
 
3.
Ogawa H, Fujimura M, Takeuchi Y, Makimura K, Satoh K. The definitive diagnostic process and successful treatment for ABPM caused by Schizophyllum commune: a report of two cases. Allergol Int 2012;61:163-169.
 
4.
Chowdhary A, Agarwal K, Kathuria S, Gaur SN, Randhawa HS, Meis JF. Allergic bronchopulmonary mycosis due to fungi other than Aspergillus: a global overview. Crit Rev Microbiol 2014;40:30-48.
 
5.
Patterson R, Greenberger PA, Halwig JM, Liotta JL, Roberts M. Allergic bronchopulmonary aspergillosis. Natural history and classification of early disease by serologic and roentgenographic studies. Arch Intern Med 1986;146:916-918.
 
6.
Agarwal R, Maskey D, Aggarwal AN, et al. Diagnostic performance of various tests and criteria employed in allergic bronchopulmonary aspergillosis: a latent class analysis. PLoS One 2013;8:e61105.
 
7.
Lee TM, Greenberger PA, Oh S, et al. Allergic bronchopulmonary candidiasis: case report and suggested diagnostic criteria. J Allergy Clin Immunol 1987;80:816-820.
 
8.
Fink JN. Therapy of allergic bronchopulmonary aspergillosis. Indian J Chest Dis Allied Sci 2000;42:221-224.
 
9.
Xavier RF, Ramos D, Ito JT, et al. Effects of Cigarette Smoking Intensity on the Mucociliary Clearance of Active Smokers. Respiration 2013;86:479-485.
 
10.
Shah A. Aspergillus-associated hypersensitivity respiratory disorders. Indian J Chest Dis Allied Sci 2008;50:117-128.
 
11.
Chowdhary A, Agarwal K, Randhawa HS, et al. A rare case of allergic bronchopulmonary mycosis caused by Alternaria alternata. Med Mycol 2012;50:890-896.
 
12.
Shah A, Maurya V, Panjabi C, Khanna P Allergic bronchopulmonary aspergillosis without clinical asthma caused by Aspergillus niger. Allergy 2004;59:236-237.
 
13.
Muscat I, Oxborrow S, Siddorn J. Allergic bronchopulmonary mycosis. Lancet 1988;1:1341-1342.
 
eISSN:1791-4914
ISSN:1105-848X
Journals System - logo
Scroll to top