Mixed Allergic Bronchopulmonary : Aspergillosis and Candidiasis
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Division of Internal Medicine, Hygeia General Hospital, Athens, Greece
Department of Pneumonology, Medical School, Democritus University of Thrace, Greece
Corresponding author
Aikaterini Spyridaki   

Hygeia Hospital, Athens, Maroussi, GR-151 23, 4 Erithrou Stavrou Str. & Kifissias Ave., Greece
Pneumon 2014;27(2):152-156
A 67 year-old woman presented with dyspnea, fever and productive cough. She was a heavy smoker (80 pack/years), with history of hypertension and alcohol consumption. Chest CT revealed bilateral diffuse infiltrates and ground glass opacities. Sputum cultures revealed multiple colonies of C. albicans and cytology showed spores and hyphae of Candida. The patient had positive skin prick test for Candida and elevated IgE level (IgE= 543 IU/mL). Allergic bronchopulmonary candidiasis was diagnosed, the patient received corticosteroids and fluconazole and showed clinical improvement. After 20 days, her symptoms reappeared as she reported poor compliance to her medication. Sputum cultures revealed A. niger colonies, one sample yielded both Aspergillus and Candida colonies. Precipitating antibodies and specific IgG and IgE against Aspergillus were present in patient's serum. Diagnosis was revised to mixed allergic bronchopulmonary aspergillosis and candidiasis. The patient received corticosteroids and voriconazole and improved.
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