Creatine kinase fluctuations in children with Obstructive sleep apnea syndrome (OSAS) Is there a relationship?
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2nd Paediatric Department, Children’s General Hospital «Panagioti and Aglaia Kyriakou», Athens, Greece
4th Paediatric Department, Medical School, Aristotle University of Thessaloniki, Greece
Medical School, Aristotle University of Thessaloniki, Greece
2nd Paediatric Department, Medical School, Aristotle University of Thessaloniki, General Hospital “AHEPA”, Thessaloniki, Greece
Corresponding author
Afroditi Sakellaropoulou   

18, Salaminos Street, Brilissia 15235 Athens, Greece
Pneumon 2017;30(2):85-91
Serum Creatine kinase (CK) activity is increased in many diseases or conditions, but in up to 10% of cases, the cause for CK elevation remains unclear. Few reports exist concerning the increase of CK in patients with OSAS. The aim of our study was to evaluate the impact of OSAS on serum CK levels in children.

Forty-two children with symptoms suggestive of OSAS were studied. The presence and severity of OSAS were assessed by full night polysomnography. Clinical, anthropometric and laboratory measurements were also recorded. Statistical analysis was performed with SPSS, version 21.0.

Based on their age and sex, elevated levels of CK were found in 4 children with OSAS only (10.3%). There was statistical important difference between CK levels and arousal index (p= 0.035, z= -2.109). Fifteen (35.71%) children with OSAS had a Waist to Hip Ratio (WHtR) cut-off point >0.50. Children with increased WHtR presented higher levels of CK compared with those with WHtR< 0.5 (p=0.055, z= 1.921).

In conclusion, it appears that a relationship between an elevation in CK concentration and chronic intermittent hypoxia exists, and might be responsible for a substantial number of cases with mild to moderate hyper CK-emia. Moreover, a correlation between CK and abdominal obesity expressed as WHtR was recorded, finding that needs to be further studied in order to be established. Therefore, nocturnal hypoxia appears to be a stimulus for changes in muscle function.

The authors have no relevant affiliations or financial involvement with any organization or entity related to the subject of this review. No writing assistance was utilized in the production of this manuscript.
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