Beyond pneumonoconiosis: Recently described occupational interstitial lung diseases
More details
Hide details
Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
Corresponding author
Evangelia Nena   

Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace 68100, Alexandroupolis, Greece
Pneumon 2010;23(3):297-300
Recent technological innovations have resulted in the introduction of new substances in different manufacturing procedures. Unfortunately, lack of knowledge of the adverse effects of some novel substances has led to the development of interstitial lung disease (ILD) among exposed workers. Exposure to diacetyl can cause bronchiolitis obliterans (“popcorn lung”), while exposure to nylon flock, Acramin-FWN, indium-tin oxide, biomass fuels or nanoparticles is associated with ILD. In addition, hypersensitivity pneumonitis can occur after exposure to additives in animal feed. Finally, new applications of substances already known to be hazardous can result in the occurrence of ILD in exposed workers.
Glazer CS, Maier L. Occupational interstitial lung disease. Eur Respir Monograph 2009;46:265–286.
Kanwal R. Bronchiolitis obliterans in workers exposed to flavoring chemicals. Cur Opin Pulm Med 2008;14:141-146.
McConnell RS, Hartle RW, International Bakers Services, Inc. Health Hazard Evaluation Report (HETA 95-171-1710). Cincinnati, OH: National Institute for Occupational Safety and Health (NIOSH), 1985.
Van Rooy FG, Rooyackers JM, Prokop M, et al. Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. Am J Respir Crit Care Med 2007;176:498- 504.
Oonakahara K, Matsuyama W, Higashimoto I, et al. Outbreak of bronchiolitis obliterans associated with consumption of Sauropus androgynus in Japan: alert of food-associated pulmonary disorders from Japan. Respiration 2005;72:221.
Volkman KK, Merrick JG, Zacaharisen MC. Yacht-maker’s lung: a case of hypersensitivity pneumonitis in yacht manufacturing. Wisc Med J 2006;105:47-50.
Eschenbacher WL, Kreiss K, Lougheed MD, et al. Nylon-flock associated interstitial lung disease. Am J Respir Crit Care Med 1999;159:2003-2008.
Lougheed MD, Roos JO, Waddell WR, et al. Desquamative interstitial pneumonitis and alveolar damage in textile workers: a potential role of mycotoxin. Chest 1995;108:1996-2000.
Antao VCS, Piacitelli CA, Miller WE, et al. Rayon flock: a new cause of respiratory morbidity in a card processing plant. Am J Ind Med 2007;50:274-284.
Atis S, Tutluoglu B, Levent E, et al. The respiratory effects of occupational polypropylene flock exposure. Eur Respir J 2005;25:110-117.
Barroso E., Ibañez MD, Aranda FI, et al. Polyethylene flockassociated interstitial lung disease in a Spanish Female. Eur Respir J 2002;20:1610-1612.
Kern DG, Kuhn C, Ely EW, et al. Flock workers' lung: broading the spectrum of clinicopathology, narrowing the spectrum of suspected etiologies. Chest 2000;117:251-259.
Weiland DA, Lynch DA, Jensen SP, et al. Thin-section CT findings in flock workers lung, a work related interstitial lung disease. Radiology 2003;227:222-231.
Kern DG, Crausman RS, Durand KT, et al. Flock workers' lung: chronic interstitial lung disease in the nylon flocking industry. Ann Intern Med 1998;129:261-272.
Moya C, Antó JM, Taylor AJ. Outbreak of organising pneumonia in textile printing sprayers. Collaborative Group for the Study of Toxicity in Textile Aerographic Factories. Lancet. 1994;344:498- 502.
Camus P, Nemery B. A novel cause for bronchiolitis obliterans organizing pneumonia: exposure to paint aerosols in textile workshops. Eur Respir J 1998;11:259-262.
Romero S, Hernández L, Gil J, Aranda I, Martín C, Sanchez-Payá J. Organizing pneumonia in textile printing workers: a clinical description. Eur Respir J. 1998;11:265-271.
Solé A, Cordero PJ, Morales P, Martínez ME, Vera F, Moya C. Epidemic outbreak of interstitial lung disease in aerographics textile workers--the "Ardystil syndrome": a first year follow up. Thorax 1996;51:94-95.
Chonan T, Taguchi O, Omae K. Interstitial pulmonary disorders in indium-processing workers. Eur Respir J 2007;29:317-324.
Homma T, Ueno T, Sekizawa K et al. Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide. J Occup Health 2003;45:137-139.
Dikensoy O, Kervancioglu R, Ege I, et al. High prevalence of diffuse parenchymal lung diseases among Turkish tinners. J Occup Health 2008;50:208-211.
Homma S, Miyamoto A, Sakamoto S et al. Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide. Eur Respir J 2005;25:200-204.
Bonner JC. Nanoparticles as a potential cause of pleural and interstitial lung disease. Proc Am Thor Soc 2010;7:138-141.
Song Y, Li X, Du X. Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma. Eur Respir J 2009; 34:559-567.
Torres-Duque C, Maldonado D, Perez-Padilla R, et al. Biomass fuels and respiratory diseases: a review of the evidence. Proc Am Thorac Soc 2008;5: 577–590.
Grobbelaar JP, Bateman ED. Hut lung: a domestically acquired pneumoconiosis of mixed aetiology in rural women. Thorax 1991;46: 334–340.
Sandoval J, Salas J, Martinez-Guerra ML, et al. Pulmonary arterial hypertension and corpulmonale associated with chronic domestic woodsmoke inhalation. Chest 1993;103:12–20.
Gold JA, Jagirdar J, Hay JG, et al. Hut lung. A domestically acquired particulate lung disease Medicine (Baltimore) 2000;79: 310–317.
Van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J 2009;33:1507-1509.
Alper F, Akgun M, Onbas O, et al. CT findings in silicosis due to denim sandblasting. Eur Radiol 2008;18:2739-2744.
Journals System - logo
Scroll to top