Beclomethasone revisited: the modern view of a classic inhaled corticosteroid
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Editorial Board Pneumon
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Petros Bakakos   

1st Depattment of Respiratory Medicine, Medical School of National and Kapodistrian University of Athens, "Sotiria" Hospial of Chest Diseases, Athens, Greece, 11 Konons Str., 116 34 Αthens, Greece
Pneumon 2014;27(2):125-130
Asthma is a worldwide problem affecting more than 300 million people of all ages with a relevant impact on quality of life and healthcare resources. International guidelines recommend the combination of a long acting beta-2-agonist and an inhaled corticosteroid when asthma is not fully controlled by low-dose ICS alone. The beclomethasone/formoterol combination is formulated as a hydrofluoroalkane-134a-containing pressurised metereddose inhaler, using the Modulite solution formulation technology. Comparative studies of this combination have shown similar efficacy versus budesonide/formoterol and fluticasone/salmeterol in patients with moderate-to-severe asthma. Several studies have indicated that inflammatory and structural changes occur in the small airways of asthmatic subjects. Beclomethasone/formoterol extra-fine formulation results in drug delivery to both central and peripheral airways, so that airway inflammation can be treated uniformly throughout the lower respiratory tract. The improved delivery of beclomethasone/formoterol extra-fine formulation translates into significant clinical benefits compared to traditional large particle inhaled medications. Despite the fixed combination of beclomethasone/formoterol delivering more drug to the lungs, it results in a lower systemic exposure. The beclomethasone/formoterol extra-fine formulation is an advantageous and safe treatment choice for patients with asthma and/or COPD.
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