Allergic Bronchopulmonary Aspergillosis due to Aspergillus niger. Report of two cases in Greece and review of the literature
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2nd Pulmonary Department, “Attikon” University Hospital, Athens Medical School, National and Kapodistrian University of Athens, Greece
6th Pulmonary Department, Athens Chest Hospital, Greece
2nd Department of Internal Medicine, “ATTIKON” General University Hospital, Medical School, University of Athens, Greece
First Department of Pediatrics, Athens Medical School, Aghia Sophia Children’s Hospital, Athens, Greece
7th Pulmonary Department and Asthma Center, Athens Chest Hospital, Greece
Corresponding author
Spyros A. Papiris   

2nd Pulmonary Medicine Department, “Attikon” University Hospital, 1 Rimini Street, 12462, Haidari
Pneumon 2014;27(4):336-339
Two cases of allergic bronchopulmonary aspergillosis (ABPA) are reported. Both patients presented severe asthma, central bronchiectasis and fleeting infiltrates on computed tomography of the chest, immediate cutaneous reactivity to Aspergillus spp, elevated total serum IgE and elevated IgG and/or IgM Aspergillus antibodies. Bronchoalveolar lavage culture documented A. niger, a very rarely encountered fungus species in this entity. Although the incidence and rate of hospitalization for asthma have increased the last decades in Greece and skin sensitization to Aspergillus is described in 5% of greek atopic patients, ABPA is scarcely reported. Untreated ABPA results in recurrent exacerbations of airway inflammation, persistent asthma and can progress to advanced fibrotic changes. Therefore high clinical suspicion, early diagnosis and timely treatment and follow-up are considered significant in the course of this rare and underdiagnosed entity.
Ab: Antibodies, A. niger: Aspergillus niger, DLCOSB: Diffusing capacity of the lung for carbon monoxide Single breath technique, HCO3: Bicarbonate, A. fumigates: Aspergillus fumigatus
All the authors declare that they do not have a financial relationship with a commercial entity that has an interest in the subject of this manuscript.
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