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REVIEW
The role of smoking cessation in lung cancer patients
Dimitrios Theofilos 1
,
 
Charalampos Marketos 1
,
 
Danai Bisirtzoglou 1
,
 
Antigoni Sakelaropoulou 1
,
 
Vasiliki Michalaki 1
,
 
Athanasios Zetos 1
,
 
George Politis 1
 
 
 
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1
Pneumonology Department, “Saint Savvas” Anticancer Hospital, Athens, Greece
 
 
Corresponding author
Dimitrios Theofilos   

Pneumonology Department, “Saint Savvas” Anticancer Hospital, Athens 171 Alexandras Av., Athens 11522, Greece
 
 
Pneumon 2015;28(4):333-339
 
Article (PDF)
References (82)
 
KEYWORDS
lung cancer
 smoking cessation
 
ABSTRACT
Lung cancer is the leading cause of death from cancer. The association of the disease with smoking is undeniable, and in the majority of cases the patients are active or former smokers. The continuation of smoking in patients with lung cancer reduces the survival and increases the risk of disease recurrence and second primary tumor incidence. Furthermore, it reduces the response to chemotherapy and or radiotherapy, delays the healing time of surgical wounds, increases the risk of postoperative complications and finally causes exacerbation of chronic diseases from which the patient may be suffering. As has been documented that smoking cessation has multiple and significant benefits for patients with lung cancer, the success of this goal in this specific patient population is a challenge. It seems that the diagnosis is a powerful incentive for patients to stop smoking, but many will require organized and systematic help. Health professionals should have an active role and education on smoking cessation methods. The opportunity to participate in smoking cessation programs should be offered to all patients and their relatives who wish to stop smoking. The treatment for smoking cessation including counseling, behavioral therapy, medication and regular monitoring, should be an integral part of treating patients with lung cancer.
FUNDING
No financial conflicts of interest.
 
REFERENCES (82)
1.
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: Cancer journal for clinicians 2011; 61:69- 90.
Google Scholar
 
 
2.
US Cancer Statistics Working Group. United States Cancer Statistics: 1999–2012 incidence and mortality web-based report. Atlanta (GA): Department of Health and Human Services, Centers for Disease Control and Prevention, and National Cancer Institute. 2015. Available at: www.cdc.gov/uscs.
Google Scholar
 
 
3.
American Cancer Society. Cancer Facts & Figures. American Cancer Society 2009.
Google Scholar
 
 
4.
Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide: IARC CancerBase No. 11 [internet]. International Agency for Research on Cancer, Lyon. globocan. iarc. fr. 2013.
Google Scholar
 
 
5.
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. European Journal of Cancer 2013;49:1374- 403.
Google Scholar
 
 
6.
Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA: A Cancer Journal for Clinicians 2007;57:43-66.
Google Scholar
 
 
7.
Cox LS, Africano NL, Tercyak KP, Taylor KL. Nicotine dependence treatment for patients with cancer. Cancer 2003;98:632-44.
Google Scholar
 
 
8.
Centers for Disease Control and Prevention (CDC). Statespecific prevalence of current cigarette smoking among adults and secondhand smoke rules and policies in homes and workplaces--United States, 2005. MMWR: Morbidity and Mortality Weekly Report 2006;55:1148.
Google Scholar
 
 
9.
Cooley ME, Sipples RL, Murphy M, Sarna L. Smoking cessation and lung cancer: oncology nurses can make a difference. In: Seminars in Oncology Nursing 2008; 24:16-26. WB Saunders.
Google Scholar
 
 
10.
Dresler CM. Is it more important to quit smoking than which chemotherapy is used? Lung Cancer 2003;39:119-24.
Google Scholar
 
 
11.
Fox JL, Rosenzweig KE, Ostroff JS. The effect of smoking status on survival following radiation therapy for non-small cell lung cancer. Lung Cancer 2004;44:287-93.
Google Scholar
 
 
12.
Nia PS, Weyler J, Colpaert C, Vermeulen P, Van Marck E, Van Schil P. Prognostic value of smoking status in operated non-small cell lung cancer. Lung Cancer 2005;47:351-9.
Google Scholar
 
 
13.
Dresler CM, Bailey M, Roper CR, Patterson GA, Cooper JD. Smoking cessation and lung cancer resection. CHEST Journal 1996;110:1199-202.
Google Scholar
 
 
14.
Dresler CM, Roper CR, Patterson GA, Cooper JD. Smoking cessation and lung cancer resection. CHEST Journal 1996;110:1199-202.
Google Scholar
 
 
15.
Gritz ER, Nisenbaum R, Elashoff RE, Holmes EC. Smoking behavior following diagnosis in patients with stage I non-small cell lung cancer. Cancer Causes & Control 1991;2:105-12.
Google Scholar
 
 
16.
Sarna L. Smoking behaviors of women after diagnosis with lung cancer. Image: The Journal of Nursing Scholarship 1995;27:35- 41.
Google Scholar
 
 
17.
Alberg AJ, Samet JM. Epidemiology of lung cancer. Chest Journal 2003;123(suppl 1):21S-49S.
Google Scholar
 
 
18.
Official Statement of the ATS Board of Directors. Cigarette smoking and health. Am J Respir Crit Care Med 1996;153:861-5.
Google Scholar
 
 
19.
Balint B, Donnelly LE, Hanazawa T, Kharitonov SA, Barnes PJ. Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke. Thorax 2001;56:456-61.
Google Scholar
 
 
20.
Catassi A, Servent D, Paleari L, Cesario A, Russo P. Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: implications on lung carcinogenesis. Mutation Research/ Reviews in Mutation Research 2008;659:221-31.
Google Scholar
 
 
21.
Yoshino I, Maehara Y. Impact of smoking status on the biological behavior of lung cancer. Surgery Today 2007;37:725-34.
Google Scholar
 
 
22.
Heeschen C, Jang JJ, Weis M, et al. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Nature Medicine 2001;7:833-9.
Google Scholar
 
 
23.
Cooke JP. Angiogenesis and the role of the endothelial nicotinic acetylcholine receptor. Life Sciences 2007;80:2347-51.
Google Scholar
 
 
24.
U.S. Department of Health and Human Services. Reducing Tobacco Use: A Report of the Surgeon General.Atlanta, Georgia: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2000.
Google Scholar
 
 
25.
Stewart AL, King AC, Killen JD, Ritter PL. Does smoking cessation improve health-related quality-of-life?. Annals of Behavioral Medicine 1995;17:331-8.
Google Scholar
 
 
26.
Garces YI, Yang P, Parkinson J, et al. The relationship between cigarette smoking and quality of life after lung cancer diagnosis. Chest Journal 2004;126:1733-41.
Google Scholar
 
 
27.
Baser S, Shannon VR, Eapen GA, et al. Smoking cessation after diagnosis of lung cancer is associated with a beneficial effect on performance status. CHEST Journal 2006;130:1784-90.
Google Scholar
 
 
28.
Leon M, Dresler C, Straif K, Baan R, Secretan B. Reversal of risk after quitting smoking. Cancer Epidemiology Biomarkers & Prevention 2006;15(Supplement 12):B46-.
Google Scholar
 
 
29.
Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to smoking: 50 years' observations on male British doctors. BJM 2004;328(7455):1519.
Google Scholar
 
 
30.
Zhou W, Heist RS, Liu G, et al. Smoking cessation before diagnosis and survival in early stage non-small cell lung cancer patients. Lung Cancer 2006;53:375-80.
Google Scholar
 
 
31.
Chen J, Qi Y, Wampfler JA, et al. Effect of cigarette smoking on quality of life in small cell lung cancer patients. European Journal of Cancer 2012;48:1593-601.
Google Scholar
 
 
32.
Parsons A, Daley A, Begh R, Aveyard P. Influence of smoking cessation after diagnosis of early stage lung cancer on prognosis: systematic review of observational studies with meta-analysis. BJM 2010 Jan 22;340.
Google Scholar
 
 
33.
Dresler CM, Patterson GA, Cooper JD. Smoking cessation and lung cancer resection. Chest Journal 1996;110:1199-202.
Google Scholar
 
 
34.
Møller AM, Villebro N, Pedersen T, Tønnesen H. Effect of preoperative smoking intervention on postoperative complications: a randomised clinical trial. The Lancet 2002;359:114-7.
Google Scholar
 
 
35.
Yildizeli B, Fadel E, Mussot S, Fabre D, Chataigner O, Dartevelle PG. Morbidity, mortality, and long-term survival after sleeve lobectomy for non-small cell lung cancer. European Journal of Cardio-Thoracic Surgery 2007;31:95-102.
Google Scholar
 
 
36.
Suzuki M, Otsuji M, Baba M, Saitoh Y. Bronchopleural fistula after lung cancer surgery: multivariate analysis of risk factors. Journal of Cardiovascular Surgery 2002;43:263.
Google Scholar
 
 
37.
Harpole DH, DeCamp MM, Daley J, et al. Prognostic models of thirty-day mortality and morbidity after major pulmonary resection. The Journal of Thoracic and Cardiovascular Surgery 1999;117:969-79.
Google Scholar
 
 
38.
Wright CD, Gaissert HA, Grab JD, O'Brien SM, Peterson ED, Allen MS. Predictors of prolonged length of stay after lobectomy for lung cancer: a Society of Thoracic Surgeons General Thoracic Surgery Database risk-adjustment model. The Annals of Thoracic Surgery 2008;85:1857-65.
Google Scholar
 
 
39.
Schwilk B, Bothner U, Schraac S, Georgieff M. Perioperative respiratory events in smokers and nonsmokers undergoing general anaesthesia. Acta Anaesthesiologica Scandinavica 1997;41:348-55.
Google Scholar
 
 
40.
Barrera R, Shi W, Amar D, et al. Smoking and timing of cessation: impact on pulmonary complications after thoracotomy. Chest Journal 2005;127:1977-83.
Google Scholar
 
 
41.
Nakagawa M, Tanaka H, Tsukuma H, Kishi Y. Relationship between the duration of the preoperative smoke-free period and the incidence of postoperative pulmonary complications after pulmonary surgery. Chest Journal 2001;120:705-10.
Google Scholar
 
 
42.
Mason DP, Subramanian S, Nowicki ER, et al. Impact of smoking cessation before resection of lung cancer: a Society of Thoracic Surgeons General Thoracic Surgery Database study. The Annals of Thoracic Surgery 2009;88:362-71.
Google Scholar
 
 
43.
Gajdos C, Hawn MT, Campagna EJ, Henderson WG, Singh JA, Houston T. Adverse effects of smoking on postoperative outcomes in cancer patients. Annals of Surgical Oncology 2012;19:1430-8.
Google Scholar
 
 
44.
Hoffmann DH. The changing cigarette, 1950-1995. Journal of Toxicology and Environmental Health Part A 1997;50:307-64.
Google Scholar
 
 
45.
Vaporciyan AA, Merriman KW, Ece F, et al. Incidence of major pulmonary morbidity after pneumonectomy: association with timing of smoking cessation. The Annals of Thoracic Surgery 2002;73:420-6.
Google Scholar
 
 
46.
Ebbert JO, Williams BA, Sun Z, et al. Duration of smoking abstinence as a predictor for non-small-cell lung cancer survival in women. Lung Cancer 2005; 47:165-72.
Google Scholar
 
 
47.
Sawabata N, Miyoshi S, Matsumura A, et al. Prognosis of smokers following resection of pathological stage I non-small-cell lung carcinoma. General Thoracic and Cardiovascular Surgery. 2007; 55:420-4.
Google Scholar
 
 
48.
Martínez-García E, Irigoyen M, Ansó E, Martínez-Irujo JJ, Rouzaut A. Recurrent exposure to nicotine differentiates human bronchial epithelial cells via epidermal growth factor receptor activation. Toxicology and Applied Pharmacology 2008; 228:334-42.
Google Scholar
 
 
49.
Zevin S, Benowitz NL. Drug interactions with tobacco smoking. Clinical Pharmacokinetics 1999; 36:425-38.
Google Scholar
 
 
50.
Miller AA, Murry DJ, Owzar K, et al. Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101. Journal of Clinical Oncology 2007; 25:3055-60.
Google Scholar
 
 
51.
Kroon LA. Drug interactions with smoking. American Journal of Health-System Pharmacy 2007;64:1917-21.
Google Scholar
 
 
52.
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al. Erlotinib in previously treated non–small-cell lung cancer. N Engl J Med 2005;353:123-32.
Google Scholar
 
 
53.
O’Malley M, King AN, Conte M, Ellingrod VL, Ramnath N. Effects of cigarette smoking on metabolism and effectiveness of systemic therapy for lung cancer. Journal of Thoracic Oncology. 2014;9:917-26
Google Scholar
 
 
54.
Matthews NE, Adams MA, Maxwell LR, Gofton TE, Graham CH. Nitric oxide-mediated regulation of chemosensitivity in cancer cells. Journal of the National Cancer Institute 2001;93:1879-85.
Google Scholar
 
 
55.
Monson JM, Stark P, Reilly JJ, et al. Clinical radiation pneumonitis and radiographic changes after thoracic radiation therapy for lung carcinoma. Cancer 1998;82:842-50.
Google Scholar
 
 
56.
Sarihan S, Ercan I, Saran A, Çetintas SK, Akalin H, Engin K. Evaluation of infections in non-small cell lung cancer patients treated with radiotherapy. Cancer Detection and Prevention 2005;29:181-8.
Google Scholar
 
 
57.
Chen J, Jiang R, Garces YI, et al. Prognostic factors for limitedstage small cell lung cancer: a study of 284 patients. Lung Cancer 2010;67:221-6.
Google Scholar
 
 
58.
Videtic GM, Stitt LW, Dar AR, et al. Continued cigarette smoking by patients receiving concurrent chemoradiotherapy for limited-stage small-cell lung cancer is associated with decreased survival. Journal of Clinical Oncology 2003;21:1544-9.
Google Scholar
 
 
59.
Cataldo JK. Clinical implications of smoking and aging: breaking through the barriers. Journal of Gerontological Nursing 2007;33:32-41.
Google Scholar
 
 
60.
Horner MJ, Ries LA, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2006, National Cancer Institute. Bethesda, MD. 2009, pp. 545-76.
Google Scholar
 
 
61.
Cancer Research UK. CancerStats. 2007. http://info.cancerresearchuk.o....
Google Scholar
 
 
62.
Shiels MS, Gibson T, Sampson J, et al. Cigarette smoking prior to first cancer and risk of second smoking-associated cancers among survivors of bladder, kidney, head and neck, and stage I lung cancers. Journal of Clinical Oncology 2014;32:3989-95.
Google Scholar
 
 
63.
Boyle JM, Tandberg DJ, Chino JP, D'Amico TA, Ready NE, Kelsey CR. Smoking history predicts for increased risk of second primary lung cancer: A comprehensive analysis. Cancer 2015;121:598-604.
Google Scholar
 
 
64.
Richardson GE, Tucker MA, Venzon DJ, et al. Smoking cessation after successful treatment of small-cell lung cancer is associated with fewer smoking-related second primary cancers. Annals of Internal Medicine 1993;119:383-90.
Google Scholar
 
 
65.
Tabuchi T, Ito Y, Ioka A, Nakayama T, Miyashiro I, Tsukuma H. Tobacco smoking and the risk of subsequent primary cancer among cancer survivors: a retrospective cohort study. Annals of Oncology 2013;24:2699-704.
Google Scholar
 
 
66.
National Comprehensive Cancer Network. NCCN guidelines version 3. 2012 Non–Small Cell Lung Cancer. Fort Washington, NCCN. 2012.
Google Scholar
 
 
67.
de Moor JS, Elder K, Emmons KM. Smoking prevention and cessation interventions for cancer survivors. In: Seminars in Oncology Nursing 2008; 24:180-92. WB Saunders.
Google Scholar
 
 
68.
Rubins J, Unger M, Colice GL. Follow-up and surveillance of the lung cancer patient following curative intent therapy. Chest Journal 2007;132:355s-67s.
Google Scholar
 
 
69.
Goodman MT, Kolonel LN, Wilkens LR, Yoshizawa CN, Le Marchand L. Smoking history and survival among lung cancer patients. Cancer Causes & Control 1990;1:155-63.
Google Scholar
 
 
70.
Silverman S, Gorsky M, Greenspan D. Tobacco usage in patients with head and neck carcinomas: a follow-up study on habit changes and second primary oral/oropharyngeal cancers. The Journal of the American Dental Association 1983;106:33-5.
Google Scholar
 
 
71.
Stevens MH, Gardner JW, Parkin JL, Johnson LP. Head and neck cancer survival and life-style change. Archives of Otolaryngology 1983;109:746-9.
Google Scholar
 
 
72.
Kawahara M, Ushijima S, Kamimori T, et al. Second primary tumours in more than 2-year disease-free survivors of smallcell lung cancer in Japan: the role of smoking cessation. British journal of cancer 1998;78:409.
Google Scholar
 
 
73.
Tucker MA, Murray N, Shaw EG, et al. Second primary cancers related to smoking and treatment of small-cell lung cancer. Journal of the National Cancer Institute 1997;89:1782-8.
Google Scholar
 
 
74.
Fujisawa T, Iizasa T, Saitoh Y, et al. Smoking before surgery predicts poor long-term survival in patients with stage I non–small-cell lung carcinomas. Journal of Clinical Oncology 1999;17:2086-91.
Google Scholar
 
 
75.
Sridhar KS, Raub WA. Present and past smoking history and other predisposing factors in 100 lung cancer patients. Chest Journal 1992;101:19-25.
Google Scholar
 
 
76.
Cooley ME, Emmons KM, Haddad R, et al. Patient‐reported receipt of and interest in smoking‐cessation interventions after a diagnosis of cancer. Cancer 2011;117:2961-9.
Google Scholar
 
 
77.
Schnoll RA, Rothman RL, Lerman C, et al. Comparing cancer patients who enroll in a smoking cessation program at a comprehensive cancer center with those who decline enrollment. Head & Neck 2004;26:278-86.
Google Scholar
 
 
78.
Walker MS, Vidrine DJ, Gritz ER, et al. Smoking relapse during the first year after treatment for early-stage non–small-cell lung cancer. Cancer Epidemiology Biomarkers & Prevention. 2006;15:2370-7.
Google Scholar
 
 
79.
Cooley ME, Wang Q, Johnson BE, et al. Factors associated with smoking abstinence among smokers and recent-quitters with lung and head and neck cancer. Lung Cancer 2012;76:144-9.
Google Scholar
 
 
80.
Gilpin EA, White MM, Farkas AJ, Pierce JP. Home smoking restrictions: which smokers have them and how they are associated with smoking behavior. Nicotine & Tobacco Research 1999;1:153-62.
Google Scholar
 
 
81.
Warren GW, Marshall JR, Cummings KM, et al. Practice patterns and perceptions of thoracic oncology providers on tobacco use and cessation in cancer patients. Journal of Thoracic Oncology (Οfficial publication of the International Association for the Study of Lung Cancer) 2013;8:543.
Google Scholar
 
 
82.
Cummings KM, Dresler CM, Field JK, et al. E-cigarettes and cancer patients. Journal of Thoracic Oncology (Οfficial publication of the International Association for the Study of Lung Cancer) 2014;9:438-41.
Google Scholar
 
 
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