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ORIGINAL STUDY
The impact of anaemia, leukocytosis and thrombocytosis on survival in patients with lung cancer resection
1
Clinic of Pneumonology, Department of Oncology, Clinical Centre of Serbia, Belgrade, Serbia
2
Department of Pneumonology and Thoracic pathology, Service for Pathology, Clinical Centre of Serbia, Belgrade, Serbia
3
Department of Pneumonology, Medical School, Democritus University of Thrace and University Hospital of Alexandroupolis, Greece
Corresponding author
Tatjana N. Adžić
Clinic for Pneumonology, Department of Oncology, Clinical Centre of Serbia, Belgrade, Serbia
Clinic for Pneumonology, Department of Oncology, Clinical Centre of Serbia, Belgrade, Serbia
Pneumon 2011;24(1):35-39
KEYWORDS
ABSTRACT
Introduction:
Previous studies have reported that preoperative leukocytosis, anaemia and thrombocytosis are related to the prognosis of non-small cell lung cancer (NSCLC). The aim of this study was to determine impact of these haematological parameters in patients of different ages with NSCLC.
Material and Methods:
Among 2,050 patients who underwent lung resection for NSCLC in the 5-year period 2002-2007, 200 were reviewed, of whom 93 were aged above 70 years.
Results:
The frequency of preoperative leukocytosis, anaemia and thrombocytosis was 21% (42/200), 32.5% (65/200), 16.5% (33/200), respectively. The 5-year survival of the patients with and without leukocytosis, anaemia and thrombocytosis was 26.5% vs 27.4%, 28.9% vs 27.2% and 31.7% vs 26.6%, respectively. No significant difference was observed in the 5-year survival according to either the presence or absence of preoperative leukocytosis, anaemia and thrombocytosis, or the age group, <70 years and ≥70 years. Significant difference was found in the haemoglobin (Hb) level between the different age groups, 3 (p=0.0025), 6 (p<0.001) and 12 (p=0.033) months postoperatively. Leukocytosis, anaemia and thrombocytosis were frequently found in earlier stages of NSCLC and in connection with extended types of surgical resection.
Conclusions:
Preoperative anaemia, leukocytosis and thrombocytosis are not related with patient survival after lung resection for NSCLC, although the measurement is inexpensive and routinely used. An abnormal blood cell count in patients with cancer is not always a tumour-related phenomenon.
Previous studies have reported that preoperative leukocytosis, anaemia and thrombocytosis are related to the prognosis of non-small cell lung cancer (NSCLC). The aim of this study was to determine impact of these haematological parameters in patients of different ages with NSCLC.
Material and Methods:
Among 2,050 patients who underwent lung resection for NSCLC in the 5-year period 2002-2007, 200 were reviewed, of whom 93 were aged above 70 years.
Results:
The frequency of preoperative leukocytosis, anaemia and thrombocytosis was 21% (42/200), 32.5% (65/200), 16.5% (33/200), respectively. The 5-year survival of the patients with and without leukocytosis, anaemia and thrombocytosis was 26.5% vs 27.4%, 28.9% vs 27.2% and 31.7% vs 26.6%, respectively. No significant difference was observed in the 5-year survival according to either the presence or absence of preoperative leukocytosis, anaemia and thrombocytosis, or the age group, <70 years and ≥70 years. Significant difference was found in the haemoglobin (Hb) level between the different age groups, 3 (p=0.0025), 6 (p<0.001) and 12 (p=0.033) months postoperatively. Leukocytosis, anaemia and thrombocytosis were frequently found in earlier stages of NSCLC and in connection with extended types of surgical resection.
Conclusions:
Preoperative anaemia, leukocytosis and thrombocytosis are not related with patient survival after lung resection for NSCLC, although the measurement is inexpensive and routinely used. An abnormal blood cell count in patients with cancer is not always a tumour-related phenomenon.
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