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EDITORIAL
Is the role of lung innate immune molecules, SP-A1 and SP-A2, and of the alveolar macrophage being overlooked in COVID-19 diverse outcomes?
1
Center for Host Defense, Inflammation,
and Lung Disease (CHILD) and
Departments of Pediatrics,
Pennsylvania State University College
of Medicine, Hershey, USA
2
Obstetrics & Gynecology,
Pennsylvania State University College
of Medicine, Hershey, USA
Pneumon 2020;33(2):1–5
KEYWORDS
CONFLICTS OF INTEREST
None
FUNDING
This work was supported by the CHILD Fund, Department of Pediatrics, Pennsylvania State University College of Medicine.
REFERENCES (42)
1.
Floros J, Wang G, Mikerov AN. Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SP-A1) and SP-A2--impact on function. Crit Rev Eukaryot Gene Expr 2009; 19:125-37.
2.
Floros J, Wang G, Lin Z. Genetic diversity of human SP-A, a molecule with innate host defense and surfactant-related functions; characteristics, primary function, and significance. Curr Pharmacogenomics 2005; 3:87-95.
3.
Floros J, Hoover RR. Genetics of the hydrophilic surfactant proteins A and D. Biochim Biophys Acta 1998; 1408:312-22. S0925-4439(98)00077-5 [pii];10.1016/s0925-4439(98)00077-5 [doi].
4.
Thorenoor N, Umstead TM, Zhang X, Phelps DS, Floros J. Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival. Front Immunol 2018; 9:2404. 10.3389/ fimmu.2018.02404 [doi].
5.
Thorenoor N, Zhang X, Umstead TM, Scott HE, Phelps DS, Floros J. Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences. Respir Res 2018; 19:23. 10.1186/s12931-018-0723-1 [doi];10.1186/ s12931-018-0723-1 [pii].
6.
D’Ovidio F, Floros J, Aramini B, et al. Donor surfactant protein A2 polymorphism and lung transplant survival. Eur Respir J 2020; 55.13993003.00618-2019 [pii];10.1183/13993003.00618- 2019 [doi].
7.
Silveyra P, Floros J. Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury. Front Biosci (Landmark Ed) 2012; 17:407-29. 3935 [pii];10.2741/3935 [doi].
8.
Floros J, Thomas NJ. Genetic variations of surfactant proteins and lung injury. In Surfactant Pathog. Treat. Lung Dis. Edited by Nakos G, Papathanasiou A. Kerala, India: Research Signpost; 2009:25-48.
9.
Gandhi CK, Chen C, Wu R, et al. Association of SNP-SNP interactions of surfactant protein genes with pediatric acute respiratory failure. Journal of Clinical Medicine 2020; 9:1183.
10.
Lin Z, Thorenoor N, Wu R, et al. Genetic Association of Pulmonary Surfactant Protein Genes, SFTPA1, SFTPA2, SFTPB, SFTPC, and SFTPD with cystic fibrosis. Front Immunol 2018; 9:2256.10.3389/fimmu.2018.02256 [doi].
11.
Wang G, Umstead TM, Hu S, Mikerov AN, Phelps DS, Floros J. Differential Effects of Human SP-A1 and SP-A2 on the BAL Proteome and Signaling Pathways in Response to Klebsiella pneumoniae and Ozone Exposure. Front Immunol 2019; 10:561.10.3389/fimmu.2019.00561 [doi].
12.
Wang G, Phelps DS, Umstead TM, Floros J. Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line. Am J Physiol Lung Cell Mol Physiol 2000, 278:L946-54. 10.1152/ajplung.2000.278.5.L946 [doi].
13.
Wang G, Umstead TM, Phelps DS, Al-Mondhiry H, Floros J. The effect of ozone exposure on the ability of human surfactant protein a variants to stimulate cytokine production. Environ Health Perspect 2002; 110:79-84. sc271_5_1835 [pii];10.1289/ ehp.0211079 [doi].
14.
Mikerov AN, Wang G, Umstead TM, et al. Surfactant protein A2 (SP-A2) variants expressed in CHO cells stimulate phagocytosis of Pseudomonas aeruginosa more than do SP-A1 variants. Infect Immun 2007; 75:1403-12. IAI.01341-06 [pii];10.1128/ IAI.01341-06 [doi].
15.
Mikerov AN, Umstead TM, Gan X, et al. Impact of ozone exposure on the phagocytic activity of human surfactant protein A (SPA) and SP-A variants. Am J Physiol Lung Cell Mol Physiol 2008; 294:L121-30. 00288.2007 [pii];10.1152/ajplung.00288.2007 [doi].
16.
Phelps DS, Umstead TM, Silveyra P, Hu S, Wang G, Floros J. Differences in the alveolar macrophage proteome in transgenic mice expressing human SP-A1 and SP-A2. J Proteom Genom Res 2013; 1:2-26. 10.14302/issn.2326-0793.jpgr-12-207 [doi].
17.
Phelps DS, Umstead TM, Floros J. Sex differences in the acute in vivo effects of different human SP-A variants on the mouse alveolar macrophage proteome. J Proteomics 2014; 108:427- 44. S1874-3919(14)00310-8 [pii];10.1016/j.jprot.2014.06.007 [doi].
18.
Noutsios GT, Thorenoor N, Zhang X, et al. SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved. Biol Sex Differ 2017; 8:37. 10.1186/ s13293-017-0158-2 [doi];10.1186/s13293-017-0158-2 [pii].
19.
Thorenoor N, Kawasawa YI, Gandhi CK, Zhang X, Floros J. Differential Impact of Co-expressed SP-A1/SP-A2 Protein on AM miRNome; Sex Differences. Front Immunol 2019; 10:1960. 10.3389/fimmu.2019.01960 [doi].
20.
Thorenoor N, Kawasawa YI, Ghandi CK, Floros J. Sex-specific regulation of gene expression networks by surfactant protein-A (SP-A) variants in alveolar macrophages in response to Klebsiella pneumoniae. Front Immunol 2020, in press:.
21.
Phelps DS, Chinchilli VM, Weisz J, Shearer D, Zhang X, Floros J. Using toponomics to characterize phenotypic diversity in alveolar macrophages from male mice treated with exogenous SP-A1. Biomark Res 2020; 8:5. 10.1186/s40364-019-0181-z [doi];181 [pii].
22.
Kim D, Quinn J, Pinsky B, Shah NH, Brown I. Rates of Co-infection Between SARS-CoV-2 and Other Respiratory Pathogens. JAMA 2020; 2764787[pii];10.1001/jama.2020.6266 [doi].
23.
LeVine AM, Gwozdz J, Stark J, Bruno M, Whitsett J, Korfhagen T. Surfactant protein-A enhances respiratory syncytial virus clearance in vivo. J Clin Invest 1999; 103:1015-1021.
24.
Watson A, Kronqvist N, Spalluto CM, et al. Novel expression of a functional trimeric fragment of human SP-A with efficacy in neutralisation of RSV. Immunobiology 2017; 222:111-8. S0171- 2985(16)30423-5 [pii];10.1016/j.imbio.2016.10.015 [doi].
25.
Thomas NJ, Diangelo S, Hess JC, et al. Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. Pediatr Res 2009; 66:70-73. 10.1203/ PDR.0b013e3181a1d768 [doi].
26.
Oosting RS, Van Iwaarden JF, Van Bree L, Verhoef J, van Golde LM, Haagsman HP. Exposure of surfactant protein A to ozone in vitro and in vivo impairs its interactions with alveolar cells. Am J Physiol 1992; 262:L63-8.
27.
Haque R, Umstead TM, Ponnuru P, et al. Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice. Toxicol Appl Pharmacol 2007; 220:72-82. S0041-008X(06)00469-8 [pii];10.1016/j.taap.2006.12.017 [doi].
28.
Stagos D, Umstead TM, Phelps DS, et al. Inhibition of ozoneinduced SP-A oxidation by plant polyphenols. Free Radic Res 2007; 41:357-66. 773163500 [pii];10.1080/10715760601064714 [doi].
29.
Samet JM, Hatch GE, Horstman D, et al. Effect of antioxidant supplementation on ozone-induced lung injury in human subjects. Am J Respir Crit Care Med 2001; 164:819-25. 10.1164/ ajrccm.164.5.2008003 [doi].
30.
Steck-Scott S, Arab L, Craft NE, Samet JM. Plasma and lung macrophage responsiveness to carotenoid supplementation and ozone exposure in humans. Eur J Clin Nutr 2004; 58:1571-9. 10.1038/sj.ejcn.1601988 [doi];1601988 [pii].
31.
Roschewski M, Lionakis MS, Sharman JP, et al. Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Sci Immunol 2020; 5.5/48/eabd0110 [pii];10.1126/sciimmunol. abd0110 [doi].
32.
Bunyavanich S, Do A, Vicencio A. Nasal Gene Expression of Angiotensin-Converting Enzyme 2 in Children and Adults. JAMA 2020; 2766524[pii];10.1001/jama.2020.8707 [doi].
33.
Noutsios GT, Willis AL, Ledford JG, Chang EH. Novel role of surfactant protein A in bacterial sinusitis. Int Forum Allergy Rhinol 2017; 7:897-903. 10.1002/alr.21985 [doi].
34.
Lopez-Rodriguez E, Pascual A, Arroyo R, Floros J, Perez-Gil J. Human Pulmonary Surfactant Protein SP-A1 Provides Maximal Efficiency of Lung Interfacial Films. Biophys J 2016; 111:524-36. S0006-3495(16)30471-4 [pii];10.1016/j.bpj.2016.06.025 [doi].
35.
Karinch AM, Floros J. Translation in vivo of 5’ untranslatedregion splice variants of human surfactant protein-A. Biochem J 1995; 307(Pt 2):327-30. 10.1042/bj3070327 [doi].
36.
Karinch AM, Deiter G, Ballard PL, Floros J. Regulation of expression of human SP-A1 and SP-A2 genes in fetal lung explant culture. Biochim Biophys Acta 1998; 1398:192-202. S0167- 4781(98)00047-5 [pii];10.1016/s0167-4781(98)00047-5 [doi].
37.
Wang G, Guo X, Floros J. Human SP-A 3’-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone. Am J Physiol Lung Cell Mol Physiol 2003; 284:L738-48. 10.1152/ajplung.00375.2002 [doi];00375.2002 [pii].
38.
Wang G, Guo X, Floros J. Differences in the translation efficiency and mRNA stability mediated by 5’-UTR splice variants of human SP-A1 and SP-A2 genes. Am J Physiol Lung Cell Mol Physiol 2005; 289:L497-L508. 00100.2005 [pii];10.1152/ ajplung.00100.2005 [doi].
39.
Wang G, Guo X, Silveyra P, Kimball SR, Floros J. Cap-independent translation of human SP-A 5’-UTR variants: a double-loop structure and cis-element contribution. Am J Physiol Lung Cell Mol Physiol 2009; 296:L635-47. 90508.2008 [pii];10.1152/ ajplung.90508.2008 [doi].
40.
Noutsios GT, Silveyra P, Bhatti F, Floros J. Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure. Am J Physiol Lung Cell Mol Physiol 2013; 304:L722-35. ajplung.00324.2012 [pii];10.1152/ajplung.00324.2012 [doi].
41.
Noutsios GT, Ghattas P, Bennett S, Floros J. 14-3-3 isoforms bind directly exon B of the 5’-UTR of human surfactant protein A2 mRNA. Am J Physiol Lung Cell Mol Physiol 2015; 309:L147-57. ajplung.00088.2015 [pii];10.1152/ajplung.00088.2015 [doi].
42.
Aramini B, Geraghty P, Lederer DJ, et al. Surfactant protein A and D polymorphisms and methylprednisolone pharmacogenetics in donor lungs. J Thorac Cardiovasc Surg 2019; 157:2109-17. S0022-5223(19)30052-2 [pii];10.1016/j.jtcvs.2018.12.098 [doi].
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