Infectious diseases in patients receiving monoclonal antibodies
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Pneumonologist, Assistant Professor of Critical Care Medicine, 2nd Critical Care Medicine Department, National and Kapodistrian University of Athens Medical School, University Hospital “Attiko”, Chaidari, Attiki, Greece
Pneumonologist, Critical Care Consultant, 2nd Critical Care Medicine Department, National and Kapodistrian University of Athens Medical School, University Hospital “Attiko”, Chaidari, Attiki, Greece
Pneumonologist, Critical Care Fellow, 2nd Critical Care Medicine Department, National and Kapodistrian University of Athens Medical School, University Hospital “Attiko”, Chaidari, Attiki, Greece
Pneumonologist, Critical Care Fellow, 2nd Critical Care Medicine Department, National and Kapodistrian University of Athens Medical School, University Hospital “Attiko”, Chaidari, Attiki, Greece.
General Surgeon, Critical Care Consultant, 2nd Critical Care Medicine Department, National and Kapodistrian University of Athens Medical School, University Hospital “Attiko”, Chaidari, Attiki, Greece
Pneumonologist, Professor of Critical Care Medicine, 2nd Critical Care Medicine Department, National and Kapodistrian University of Athens Medical School, University Hospital “Attiko”, Chaidari, Attiki, Greece
George Dimopoulos   

University of Athens, University Hospital “Attiko”, Rimini 1, 12462, Chaidari
Pneumon 2012;25(4):402–409
Monoclonal antibodies (MA) act against specific antigens and are indicated for the treatment of inflammatory and neoplastic diseases as well as in the control of immune responses in transplant patients. More than 30 MA are currently in use in clinical practice, including rituximab, targeting the CD-20 antigen of B lymphocytes, bevacizumab against vascular endothelial growth factor (VEGF), infliximab and adalimubab against tumour necrosis factor alpha (TNF-α) and omalizumab, which neutralizes circulating IgE. The use of MA has been associated with infective complications due to their immunomodulatory action. The prevalence of herpes virus infections, Pneumocystis jirovecii pneumonia and Mycoplasma tuberculosis infection is increased in patients receiving MA. Prevention of these infective complications is based on the clinical evaluation of patients before treatment with MA and close monitoring of the parameters associated with infections during treatment.
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