Hot topics in IPF Pathogenesis: ERS and ATS highlights

Selman M, Pardo A. Revealing the pathogenic and agingrelated mechanisms of the enigmatic idiopathic pulmonary fibrosis. an integral model. American Journal of Respiratory and Critical Care Medicine 2014; 189:1161-72.

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Bueno M, Lai YC, Romero Y, et al. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. The Journal of Clinical Investigation 2015; 125:521-38.

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Vasarmidi E, Tsitoura E, Margaritopoulos G, et al. IPF BALF Cells Show Reduced Expression of PINK1 Coupled To Elevated Oxidized Mitochondria Levels. American Thoracic Society International Conference Abstracts. 2016; Poster Session B57.

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Carmen MS, Ivan A, Francesca M, et al. Alveolar Macrophage Activation Pattern in Idiopathic Pulmonary Fibrosis (IPF): Bronchoalveolar Lavage (BAL) Transcriptome Analysis. D27 MACROPHAGES: RESOLVERS, RESPONDERS OR BOTH?: American Thoracic Society); 2016, pp. A6600-A6600.

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Larson-Casey JL, Deshane JS, Ryan AJ, Thannickal VJ, Carter AB. Macrophage Akt1 Kinase-Mediated Mitophagy Modulates Apoptosis Resistance and Pulmonary Fibrosis. Immunity 2016; 44:582-96.

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Snetselaar R, van Moorsel CH, Kazemier KM, et al. Telomere Length in Interstitial Lung Diseases. Chest 2015; 148:1011-8.

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Alder JK, Stanley SE, Wagner CL, Hamilton M, Hanumanthu VS, Armanios M. Exome sequencing identifies mutant TINF2 in a family with pulmonary fibrosis. Chest 2015; 147:1361-8.

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Kropski JA, Mitchell DB, Markin C, et al. A novel dyskerin (DKC1) mutation is associated with familial interstitial pneumonia. Chest 2014; 146:e1-7.

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Kannengiesser C, Borie R, Menard C, et al. Heterozygous RTEL1 mutations are associated with familial pulmonary fibrosis. Eur Respir J 2015; 46:474-85.

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10.

Stuart BD, Choi J, Zaidi S, et al. Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening. Nat Genet 2015; 47:512-7.

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11.

Oldham JM, Ma SF, Martinez FJ, et al and Investigators IP. TOLLIP, MUC5B and the Response to N-acetylcysteine Among Individuals with Idiopathic Pulmonary Fibrosis. American journal of respiratory and critical care medicine. 2015.

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12.

Shah JA, Vary JC, Chau TT, et al. Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis. Journal of Immunology 2012; 189:1737-46.

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13.

Van der Vis J, Snetselaar R, Kazemier K, Grutters J, Van Moorsel C. The effect of MUC5B promoter polymorphism on susceptibility to idiopathic interstitial pneumonias and cell profiles in bronchoalveolar Lavage fluid. ERJ 2015; 46(suppl 59).

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14.

Ohshimo S, Yamaoka C, Horimasu Y, et al. Comparative analysis of multiple gene polymorphisms for acute exacerbation of idiopathic pulmonary fibrosis. ERJ 2015; 46(suppl 59).

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15.

Molyneaux P, Cookson W, Moffatt M, Kim DS, Maher T. LSC Abstract – Changes in the respiratory microbiome during acute exacerbations of Idiopathic Pulmonary Fibrosis. ERJ 2015; 46(suppl 59).

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ISSN:	1105-848X