Highlights of Early Pulmonary Surfactant: Research from Bench to Clinic
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Center for Host Defense, Inflammation, and Lung Disease CHILD Research Department of Pediatrics, The Pennsylvania State University, Hershey, Pennsylvania, USA
Department of Obstetrics and Gynecology, College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, USA
Joanna Floros   

Department of Pediatrics 500 University Drive MC H085 Hershey, Pennsylvania 17033 USA,
Pneumon 2013;26(4):350–354
Nowadays we know a great deal about the lung. We understand its major functions, how it achieves most of these, how it looks microscopically, and other physiological attributes such as that adequate amounts of pulmonary surfactant in the prematurely born infant are essential for lung function and consequently for life. In this review, we summarize highlights of the history, i.e. the journey of pulmonary surfactant discovery and how it moved from the lab bench to the patient’s bedside.
FDA= Food and Drug Administration, NIH= National Institutes of Health, DPPC= dipalmitoyl phosphatidylcholine, SP-= surfactant proteins, BAL= bronchoalveolar lavage, RDS= respiratory distress syndrome, SP-A= surfactant protein A, AMs= alveolar macrophages, UTR= untranslated region
This work was supported by the NIH HL34788 grant.
No conflicts of interest, financial or otherwise are declared by the author(s).
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