Assessing the budget impact of nintedanib for the treatment of idiopathic pulmonary fibrosis in the Greek healthcare setting
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University of Peloponnese, Corinth, Greece
Health Policy Institute, Athens, Greece
University of Athens, Athens, Greece
Demosthenes Bouros   

First Academic Department of Pneumonology, Hospital for Diseases of the Chest, “Sotiria”, Medical School, National and Kapodistrian University of Athens 152 Messogion Aven., Athens 11527, Greece
Pneumon 2018;31(4):205–211
Idiopathic pulmonary fibrosis (IPF) is a rare, chronic lung disease with a high mortality rate. IPF affects about 5 million people worldwide with median survival being 2-5 years following diagnosis. Until recently, there was no licensed pharmacologic therapy available for IPF and patients were managed by best supportive care, that includes treatment with pirfenidone. In 2015, nintedanib was approved for the treatment of IPF. This study estimates the reimbursement of nintedanib and its budget impact on the National Organization for Health Care Services Provision (EOPPY). The budget impact of reimbursing nintedanib as part of already available treatment options corresponds to a maximum of 0.13% of annual total pharmaceutical expenditure. Therefore, it has a relatively low impact on the budget of EOPPY, while use of nintedanib was associated with a higher number of acute exacerbation events being avoided, thus providing additional cost savings to EOPPY.
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
This paper was not funded.
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Greek legislated DRGs 2012-2017 - Υ4α/οικ.105494 ΚΥΑ (ΦΕΚ 3096/Β/2012), Υ4α/οικ.50142 ΚΥΑ (ΦΕΚ 1474/Β/2014), Α3γ/ οικ.76490 ΚΥΑ (ΦΕΚ 3395/Β/2016), Α3γ/οικ.1846 ΚΥΑ (ΦΕΚ 117/Β/2017).